Table 2.
Summary of CV Toxicity Characteristicsa
| Characteristic | Total (N=31) N (%) |
|---|---|
| CV toxicity type | |
| CHF with reduced EF | 6 (19.4) |
| CHF with preserved EF | 7 (22.6) |
| Hypertension | 8 (25.8) |
| Edema | 23 (74.2) |
| Pericardial effusion | 1 (3.2) |
| Other | 8 (25.8) |
| Clinician initial action | |
| Continue itraconazole regimen | 2 (4.5) |
| Discontinue itraconazole | 23 (74.2) |
| Modify itraconazole dose | 6 (19.4) |
| Outcome | |
| Complete resolution | 17 (54.8) |
| Partial resolution | 9 (29) |
| No resolution | 4 (12.9) |
| Unknown | 1 (3.2) |
| Clinician subsequent action taken | |
| Yes | 6 (19.4) |
| No | 26 (80.6) |
CV = cardiovascular; CHF = congestive heart failure; EF = ejection fraction.
a
Percentages add up to >100%, as many patients had ≥1 CV toxicity.