Figure 1.
Schematic diagram showing the structure of the final pharmacokinetic model. Abbreviations: CLC = central clearance; CLLC = distribution clearance from lung to central compartment; Q = intercompartmental clearance; C = central compartment; L = lung compartment; P = peripheral tissue compartment; Dd = solution compartment for dissolved drugs; Ds = suspension compartment for solid drug particles in the suspension; Fd = fraction dissolved; kd = dissolution rate constant, where kd = kd0·(e–kdt1·t + e–kdt2·t), and kd0 = dissolution rate constant at time 0, kdt1 = first decline rate constant of kd, and kdt2 = second decline rate constant of kd.