. 2020 Sep 22;5(40):25733–25746. doi: 10.1021/acsomega.0c03004

Table 3. Metabolic Stabilities of SEN023, SEN066, and SEN089 in Human Liver Microsomes^a.

CPD	half-life (min)	CL_int (mL/min)	CL_H (mL/min)	EE
SEN023	67.51	1201.17	667.03	0.44
SEN066	106.73	759.72	504.30	0.34
SEN089	21.25	3816.07	1076.76	0.72

Abbreviations: CPD = compound; CL_int = intrinsic clearance; CL_H = hepatic clearance; EE = extraction efficiency.

Table 3. Metabolic Stabilities of SEN023, SEN066, and SEN089 in Human Liver Microsomesa.