Table 5. Summary of PK Indices across the Study Design Space for SEN023, SEN066, and SEN089a.
| CPD | AUCLT | AUCLD | AUCPL | CMXLT | CMXLD | CMXPL | TATLT | TATLD | TATPL | |
|---|---|---|---|---|---|---|---|---|---|---|
| (μg/L·h) | (μg/L) | (%) | ||||||||
| SEN023 | max | 222131.3 | 5720.5 | 395.1 | 46583.9 | 46583.9 | 1613.1 | 100.0 | 3.4 | 0.7 |
| min | 5720.5 | 2696.3 | 347.3 | 46583.9 | 4658.4 | 209.0 | 1.1 | 0.7 | 0.0 | |
| ratio | 38.8 | 2.1 | 1.1 | 1.0 | 10.0 | 7.7 | 90.9 | 4.9 | NA | |
| SEN066 | max | 314073.5 | 5545.2 | 205.3 | 45592.7 | 45592.7 | 1101.1 | 100.0 | 3.0 | 0.4 |
| min | 5545.2 | 2289.3 | 148.1 | 45592.7 | 4559.3 | 153.5 | 0.9 | 0.6 | 0.0 | |
| ratio | 56.6 | 2.4 | 1.4 | 1.0 | 10.0 | 7.2 | 111.1 | 5.0 | NA | |
| SEN089 | max | 182530.9 | 3881.0 | 985.4 | 25125.6 | 25125.6 | 4002.7 | 100.0 | 3.2 | 1.7 |
| min | 3881.0 | 1965.3 | 796.1 | 25125.6 | 2512.6 | 531.6 | 1.5 | 0.6 | 0.0 | |
| ratio | 47.0 | 2.0 | 1.2 | 1.0 | 10.0 | 7.5 | 66.7 | 5.3 | NA | |
a
Abbreviations: CPD = compound; AUC = area-under-the-curve at 24 h; CMX = maximum concentration; TAT = %T > target; LT = total lung drug concentrations; LD = dissolved lung drug concentrations; PL = plasma drug concentrations; NA = not applicable.