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. 2020 Sep 30;5(40):25625–25633. doi: 10.1021/acsomega.0c02564

Figure 2.

Figure 2

Evaluation of normalization and missing values. (A) Sum of normalized intensities using VSN by sample. (B) Principal component analysis plot based on data normalized by VSN. (C) Sample-clustered heatmap of missing values. (D) Pooled intragroup coefficient of variance comparing different normalization methods. (E) Pooled intragroup estimate of variance comparing different normalization methods. (F) Pooled intragroup median absolute deviation comparing different normalization methods. (G) Pairwise sample correlations within a group for different normalization methods. (H) Correlation heatmap (all pairwise samples). (I) Distribution of log2-ratios (all two-group combinations) for different normalization methods.