Figure 1.

Detrimental effects of rs9349379-G allele on coronary microvascular function and endothelin-1. (A) Patients with G allele were over twice as likely to have underlying microvascular dysfunction (odds ratio per G allele 2.33, 95% confidence interval 1.10–4.96; P = 0.027) Even after adjustment for other risk factors the G allele was predictive of microvascular disease (odds ratio 2.31; 95% confidence interval 1.0–4.91). This finding supports a detrimental impact on the coronary microcirculation of a lifetime of increased endothelin gene expression. (B) In a multivariable regression model adjusting for baseline group differences, patients with rs9349379-G allele had higher plasma endothelin-1 (least squares mean 1.59 pg/mL vs. 1.28 pg/mL; 95% confidence interval 0.10–0.53; P = 0.005).