Figure 3.

Genotype: phenotype association of G allele with non-invasive ischaemia testing. (A) Cardiovascular stress magnetic resonance imaging at 1.5 T (N = 107). There was a linear relationship between the G allele and presence of an inducible perfusion defect on cardiac magnetic resonance (χ² test for linear trend P = 0.042). (B) The relationship was more robust when considering with invasive evidence of coronary microvascular dysfunction and/or inducible perfusion defect. Over 90% of GG subjects had at least one abnormality compared with only 65% of AA subjects (P < 0.001). (C and D) Myocardial perfusion reserve was numerically reduced in AG and GG subjects compared with AA subjects; however, this was not statistically significant (P-value represents analysis of variance test for trend). Error bars represent 95% confidence intervals for the mean. (E) Invasive evidence of microvascular dysfunction (defined by abnormal response to intracoronary acetylcholine and/or systemic adenosine) was functionally significant and associated with ischaemic burden on symptom limited exercise treadmill testing (coronary microvascular dysfunction −2.3 vs. no coronary microvascular dysfunction +3.5; difference −5.8 units; −8.2 to −3.3; P < 0.001). (F) Exercise treadmill testing (n = 84). There was a relationship between genotype group and worsening ischaemia on stress testing (analysis of variance P-trend = 0.045). The mean difference in ischaemia by Duke treadmill score between group GG and group AA was −3.0 units (95% confidence interval −5.8 to −0.1; P = 0.045). Error bars represent 95% confidence intervals for the mean.