| Human recombinant Neuregulin 1 (rhNRG1β) |
Neucardin |
β-Isoform of the growth factor domain (EGF- domain) of NRG-1 |
Liu et al. [83], Gu et al. [180], Guo et al. [181], Fang et al. [182] |
Jabbour et al. [116], Gao et al. [117] |
Both phase 1 and 2 trials have been completed finding sustained improvement in LVEF in systolic heart failure patients at 90-day follow-up. A phase 3 trial is currently on going. |
| Human recombinant Neuregulin 1 (rdNRG1β) |
None |
β-Isoform of the growth factor domain (EGF- domain) of NRG-1 with Ig domain |
Bersell et al. [89] |
None. |
None |
| Human recombinant glial growth factor 2 isoform of NRG1β (GGF2) |
Cimaglermin Alfa |
β-isoform of the growth factor domain (EGF- domain), type 2 isoform of NRG-1 gene, containing IgG and kringle domains |
Bian et al [183], Hill et al. [184], Galindo et al. [95] |
Lenihan et al. [118] |
A phase 1 trial was completed finding sustained improvement in LVEF in systolic heart failure patients. There was a dose limiting side effect at the highest planned dose. See the text for details. |
| Engineered bivalent NRG1β (bivNRG) |
None |
2 β-Isoform of the growth factor domain (EGF- domain) of NRG-1 connected by a linking peptide |
Jay et al. [145] |
None |
None |
