Fig. 7. Chemical structures and binding modes with the target protein: (a) dimethyl fumarate binding to Cys-599 (PDB ID 5O1S), (b) EGFR kinase inhibitor dacomitinib, binding Cys-797 (PDB ID ; 4I24), (c) ibrutinib (PDB ID ; 5P9J), and (d) zanubrutinib (PDB ID ; 6J6M) binding to Cys-481 of BTK. Inhibitors are shown as cyan sticks and Cys-599, Cys-797, Cys-481 are shown as yellow sticks.