Table 2. Examples of covalent inhibitors in clinical trials.

No.	Structure and name	Target (therapeutic)	Warhead	Clinical stage
1	PRN1008	BTK inhibitor	α,β-Unsaturated carbonyl	III
2	Evobrutinib	BTK inhibitor	α,β-Unsaturated carbonyl	III
3	AMG510	KRAS inhibitor	α,β-Unsaturated carbonyl	II
4	Poziotinib	EGFR inhibitor	α,β-Unsaturated carbonyl	II
5	PF-06651600	JAK3 inhibitor	α,β-Unsaturated carbonyl	II
6	Remibrutinib	BTK inhibitor	α,β-Unsaturated carbonyl	II
7	Futibatinib	FGFR inhibitor	α,β-Unsaturated carbonyl	II
8	Tirabrutinib	BTK inhibitor	α,β-Unsaturated propargylamide	II
9	Spebrutinib	BTK inhibitor	α,β-Unsaturated carbonyl	II