Table 1.

Summary of major pharmacokinetic characteristics of various drug inhibition models.

Characteristics	Inhibitor Type
	Competitive	Non-Competitive Non-Mechanism Based	Mechanism-Based
Metabolism required	No	No	Yes
Active site mediated	Yes	No	Yes
Time dependent	No	No	Yes
Substrate concentration dependent	Yes	No	Yes
Km (victim drug)	↑	↔	↔
Vmax (victim drug)	↔	↓	↓
CLint (victim drug)	↓	↓	↓