Table 1.
Descriptives at each time point
| Baseline | 12 months | |||||
|---|---|---|---|---|---|---|
| n | Mean | s.d./IQR | n | Mean | s.d./IQR | |
| Waist circumference (cm), men | 102 | 90.2 | 12.1 | 66 | 93.4 | 13.7 |
| Waist circumference (cm), women | 59 | 88.8 | 16.1 | 44 | 89.8 | 16.8 |
| Systolic blood pressure (mm/Hg) | 219 | 117.4 | 15.6 | 147 | 118.4 | 15.6 |
| Diastolic blood pressure (mm/Hg) | 219 | 75.0 | 12.0 | 147 | 77.4 | 12.0 |
| Cholesterol (mmol/L) | 186 | 4.8 | 1.0 | 114 | 4.8 | 1.1 |
| High density lipoprotein (mmol/L) | 179 | 1.4 | 0.4 | 110 | 1.3 | 0.4 |
| Triglycerides (mmol/L) | 175 | 1.4 | 0.9 | 100 | 1.3 | 0.9 |
| Height (cm), men | 126 | 176.6 | 7.9 | – | – | – |
| Height (cm), women | 68 | 165.5 | 7.7 | – | – | – |
| Weight (kg), men | 123 | 80.0 | 15.7 | 66 | 86.0 | 17.6 |
| Weight (kg), women | 64 | 71.3 | 19.4 | 43 | 73.2 | 19.3 |
| BMI (kg/m2), men | 119 | 25.5 | 4.6 | 57 | 27.2 | 5.3 |
| BMI (kg/m2), women | 61 | 26.0 | 6.3 | 36 | 26.6 | 5.4 |
| HbA1c (mmol/mol) | 167 | 35.5 | 7.1 | 93 | 37.7 | 8.3 |
| Fasting glucose (mmol/L) | 173 | 4.8 | 0.9 | 95 | 5.1 | 1.9 |
| C-reactive protein (mg/L)a | 168 | 1 | 0.3–2.6 | 93 | 1.5 | 0.5–3.5 |
| Insulin (mU/L)a | 125 | 10.1 | 5.2–15.3 | 60 | 8.8 | 5.0–14.6 |
| HOMA IRa,b | 121 | 2.1 | 1.2–3.2 | 57 | 1.8 | 1.0–2.7 |
| AUDIT hazardous drinking score | 199 | 9.4 | 9.5 | 115 | 5.8 | 6.9 |
| DINE fat intake score | 186 | 32.8 | 13.5 | 114 | 30.7 | 13.2 |
| IPAQ, mean h sitting per day | 178 | 8.1 | 4.2 | 110 | 8.3 | 4.2 |
| PANSS total scorec | 190 | 58.2 | 15.0 | 114 | 51.0 | 15.6 |
| GAF symptoms score | 175 | 51.3 | 20.5 | 116 | 62.9 | 17.5 |
| GAF disability score | 174 | 56.6 | 18.1 | 115 | 64.8 | 17.8 |
| CGI severity scale scorea | 198 | 3 | 2–4 | 116 | 2 | 1–4 |
| CGI improvement scale scorea | – | – | – | 111 | 1 | 0–2 |
| Calgary Depression Scale total scorea,c | 187 | 4 | 1–9 | 118 | 3 | 1–8 |
| YMRS scorea,c | 185 | 4 | 2–8 | 117 | 2 | 0–5 |
s.d., standard deviation; IQR, interquartile range; BMI, body mass index; HbA1c, haemoglobin A1c; HOMA IR, homeostasis model assessment – insulin resistance; AUDIT, Alcohol Use Disorders Identification Test; DINE, Dietary Instrument for Nutrition Education; IPAQ, International Physical Activity Questionnaire; PANSS, Positive and Negative Symptom Scale; GAF, Global Assessment of Functioning; CGI, Clinical Global Impression Scale; YMRS, Young Mania Rating Scale.
a. Medians and upper/lower quartiles presented instead of means standard deviations because of skewed data.
b. Values of fasting glucose over 11 mmol/L were excluded from the calculation of HOMA IR.
c. PANSS, Calgary and YMRS totals were calculated even where individual items were missing (although PANSS was considered missing if any of the three subscale totals, positive symptoms, negative symptoms and general psychopathology were entirely missing).