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. 2020 Sep 25;37(3):301–310. doi: 10.5511/plantbiotechnology.20.0421a

Figure 1. Biosynthesis of (+)-pisatin and related compounds. Names of skeletons and individual compounds are shown in bold and plain fonts, respectively. Isoflav-3-enes are shown inside the dotted-line frame. Biosynthesis of isoflavones and 2′-hydroxyisoflavones shown here constitutes a metabolic grid, and enzymes involved are shown in parentheses. Constituents of isoflavonoids of leguminous plants are as follows: (6a) Glycyrrhiza spp. and Medicago spp., (6b) Maackia spp., Cicer spp., and Trifollium spp., (7a) Styphnolobium japonicum, (7c) Pisum sativum, (8) Glycine max, Glycyrrhiza spp., Lotus japonicus, and Medicago spp., (9) Cicer spp., (10) Lespedeza homoloba, and (11) Vigna unguiculate. Abbreviations: IFS, 2-hydroxyisoflavanone synthase; HID, 2-hydroxyisoflavanone dehydratase; HI4′OMT, 2-hydroxyisoflavanone 4′-O-methyltransferase; I2′H, isoflavone 2′-hydroxylase; I3′H, isoflavone 3′-hydroxylase; I3S, isoflav-3-ene synthase; IFR, isoflavone reductase; I4R, 2′-hydroxyisoflavanone 4-reductase; PBS, pseudobaptigenin synthase; PTS, pterocarpan synthase; SOR, sophorol reductase; VR, vestitone reductase; 2′HF, 2′-hydroxyformononetin; DMD, 7,2′-dihydroxy-4′,5′-methylenedioxyisoflavone; DMI, 7,2′-dihydroxy-4′-methoxyisoflavanol; DMDI, 7,2′-dihydroxy-4′,5′-methylenedioxyisoflavanol; DMIF, 7,2′-dihydroxy-4′-methoxyisoflav-3-ene; DMDIF, 7,2′-dihydroxy-4′,5′-methylenedioxyisoflav-3-ene; THIF, 7,2′,4′-trihydroxyisoflav-3-ene.

Figure 1. Biosynthesis of (+)-pisatin and related compounds. Names of skeletons and individual compounds are shown in bold and plain fonts, respectively. Isoflav-3-enes are shown inside the dotted-line frame. Biosynthesis of isoflavones and 2′-hydroxyisoflavones shown here constitutes a metabolic grid, and enzymes involved are shown in parentheses. Constituents of isoflavonoids of leguminous plants are as follows: (6a) Glycyrrhiza spp. and Medicago spp., (6b) Maackia spp., Cicer spp., and Trifollium spp., (7a) Styphnolobium japonicum, (7c) Pisum sativum, (8) Glycine max, Glycyrrhiza spp., Lotus japonicus, and Medicago spp., (9) Cicer spp., (10) Lespedeza homoloba, and (11) Vigna unguiculate. Abbreviations: IFS, 2-hydroxyisoflavanone synthase; HID, 2-hydroxyisoflavanone dehydratase; HI4′OMT, 2-hydroxyisoflavanone 4′-O-methyltransferase; I2′H, isoflavone 2′-hydroxylase; I3′H, isoflavone 3′-hydroxylase; I3S, isoflav-3-ene synthase; IFR, isoflavone reductase; I4R, 2′-hydroxyisoflavanone 4-reductase; PBS, pseudobaptigenin synthase; PTS, pterocarpan synthase; SOR, sophorol reductase; VR, vestitone reductase; 2′HF, 2′-hydroxyformononetin; DMD, 7,2′-dihydroxy-4′,5′-methylenedioxyisoflavone; DMI, 7,2′-dihydroxy-4′-methoxyisoflavanol; DMDI, 7,2′-dihydroxy-4′,5′-methylenedioxyisoflavanol; DMIF, 7,2′-dihydroxy-4′-methoxyisoflav-3-ene; DMDIF, 7,2′-dihydroxy-4′,5′-methylenedioxyisoflav-3-ene; THIF, 7,2′,4′-trihydroxyisoflav-3-ene.