. 2020 Oct 14;6(1):58–66. doi: 10.1001/jamacardio.2020.4876

Table 1. Clinical, Obstetric, and Aortic Imaging Data in Women With Pregnancy-Related Acute Aortic Dissection.

Patient No.	Aortopathy diagnosis	Diagnosis Ghent or revised Ghent; genetic testing	Aortopathy diagnosis before vs after dissection	Prior aortic surgery	Aortic dissection type	Time of dissection	Treatment	Aortic diameter, mm		β-Blocker use	Hypertension^a	Mode of delivery	Prior pregnancy
Patient No.	Aortopathy diagnosis	Diagnosis Ghent or revised Ghent; genetic testing	Aortopathy diagnosis before vs after dissection	Prior aortic surgery	Aortic dissection type	Time of dissection	Treatment	Before aortic dissection	At time of diagnosis of aortic dissection	β-Blocker use	Hypertension^a	Mode of delivery	Prior pregnancy
1	Marfan	NA	NA	No	A	3rd TM	Surgery	47 SoV	52 SoV; 53 AA	No	No	Cesarean	Yes
2	Marfan	Ghent FBN1	Before	No	A	28 d PP	Surgery	45 SoV	45 SoV; 48 AA; 35 DA	Yes	No	Vaginal	No
3	Marfan	Ghent	After	No	A	6 d PP	Surgery	NA	76 SoV; 70 AA	No	No	Cesarean	Yes
4	Marfan	Ghent FBN1	Before	No	A	3rd TM	Surgery	41 SoV	50 SoV; 42 AA; 27 DA	Yes	No	Cesarean	No
5	Marfan	Revised Ghent	After	No	A	3rd TM	Surgery	NA	52 SoV; 60 AA; 25 DA	No	No	Cesarean	Yes
6	Marfan	Revised Ghent FBN1	After	No	A	3rd TM	Surgery	NA	60 SoV; 68 AA; 22 DA	No	No	Cesarean	Yes
7	Marfan	NA	NA	No	A	NA	Surgery	NA	42 SoV; 50 AA; 24 DA	NA	NA	NA	NA
8	BAV	No genetic testing	After	No	A	3rd TM	Surgery	No	52 SoV; 46 AA; 24 DA	No	No	Cesarean	No
9	BAV	No genetic testing	After	No	A	3rd TM	Surgery	NA	NA	No	Yes	Cesarean	No
10	FTAA	No genetic testing	After	No	A	2 d PP	Surgery	NA	60 SoV; 70 AA	No	No	Cesarean	No
11	+FH aortic disease	Genetic testing: no variants	NA	No	A	NA	Surgery	41 SoV	42 AA; 21 DA	No	Yes	Cesarean	Yes
12	None	NA	NA	No	A	4 d PP	Surgery	NA	63 SoV; 55 AA; 24 DA	No	No	Vaginal	No
13	None	NA	NA	No	A	3rd TM	Surgery	NA	47 SoV; 40 AA; 44 DA	NA	Yes	Cesarean	Yes
14	Marfan	Ghent FBN1	Before	No	B	10 d PP	Medical	NA	39 SoV; 29 AA; 28 DA	NA	No	Vaginal	Yes
15	Marfan	Ghent FBN1	Before	VSRR	B	3rd TM	Medical	20 DA	35 SoV; 28 AA; 30 DA	Yes	No	Cesarean	Yes
16	Marfan	Revised Ghent FBN1	Before	No	B	5 d PP	Medical	22 DA	28 AA; 27 DA	Yes	No	Vaginal	Yes
17	Marfan	Revised Ghent FBN1	Before	No	B	1st TM	Surgery	NA	40 SoV; 60 DA	Yes	Yes	Termination	Yes
18	Marfan	Revised Ghent FBN1	After	No	B	3rd TM	TEVAR	36 SoV	33 SoV; 24 AA; 23 DA	Yes	No	Cesarean	No
19	Marfan	Revised Ghent	NA	No	B	5 d PP	Medical	41 SoV	38 SoV	Yes	No	Cesarean	Yes
19	Marfan	Revised Ghent	NA	No	B	5 d PP	Medical	41 SoV	29 DA	Yes	No	Cesarean	Yes
20	Loeys-Dietz	TGFBR1	Before	No	B	56 d PP	Surgery	42 SoV; 30 AA; 36 DA	47 SoV; 45 AA; 57 DA	Yes	No	Cesarean	No
21	Loeys-Dietz	TGFBR1	Before	VSRR	B	3 d PP	Surgery	28 DA	33 SoV; 35 AA; 32 DA	Yes	No	Cesarean	No
22	+FH aortic disease	Genetic testing: no variants	NA	No	B	10 d PP	TEVAR	22 DA	27 SoV; 30 AA; 30 DA	No	No	Vaginal	Yes
23	None	NA	NA	VSRR	B	3rd TM	Surgery	NA	35 SoV	NA	NA	Cesarean	NA
24	None	Genetic testing: no variants	NA	None	B	11 d PP	Medical	NA	27 SoV; 26 AA; 24 DA	No	No	Vaginal	Yes
25	None	NA	NA	No	B	1st TM	TEVAR	NA	40 SoV; 39 AA; 27 DA	No	Yes	MC	Yes
26	None	NA	NA	No	B	1st TM	Medical	NA	31 SoV; 34 AA; 24 DA	No	No	Vaginal	No
27	None	NA	NA	Prior type B aortic dissection	B	1st TM	Medical	NA	24 AA; 29 DA	No	Yes	Termination	NA
28	None	NA	NA	No	B	10 d PP	Medical	NA	31 SoV; 36 AA; 31 DA	No	Yes, PE	Cesarean	Yes
29	None	COL5A1 VUS	NA	No	B	3rd TM	Medical	NA	26 SoV; 26 AA; 35 DA	No	No	Vaginal	Yes

Abbreviations: AA, ascending aorta; BAV, bicuspid aortic valve; DA, descending aorta; +FH, positive family history; FTAA, familial thoracic aortic aneurysm; MC, miscarriage; NA, not available; PE, preeclampsia; PP, post partum; SoV, sinus of Valsalva; TEVAR, thoracic endovascular aortic repair; TM, trimester; VSRR, valve-sparing root replacement; VUS, variant of unknown significance.

^{^a}

Hypertension or hypertensive disorder during pregnancy.