Table 1. Clinical, Obstetric, and Aortic Imaging Data in Women With Pregnancy-Related Acute Aortic Dissection.
Patient No. | Aortopathy diagnosis | Diagnosis Ghent or revised Ghent; genetic testing | Aortopathy diagnosis before vs after dissection | Prior aortic surgery | Aortic dissection type | Time of dissection | Treatment | Aortic diameter, mm | β-Blocker use | Hypertensiona | Mode of delivery | Prior pregnancy | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Before aortic dissection | At time of diagnosis of aortic dissection | ||||||||||||
1 | Marfan | NA | NA | No | A | 3rd TM | Surgery | 47 SoV | 52 SoV; 53 AA | No | No | Cesarean | Yes |
2 | Marfan | Ghent FBN1 | Before | No | A | 28 d PP | Surgery | 45 SoV | 45 SoV; 48 AA; 35 DA | Yes | No | Vaginal | No |
3 | Marfan | Ghent | After | No | A | 6 d PP | Surgery | NA | 76 SoV; 70 AA | No | No | Cesarean | Yes |
4 | Marfan | Ghent FBN1 | Before | No | A | 3rd TM | Surgery | 41 SoV | 50 SoV; 42 AA; 27 DA | Yes | No | Cesarean | No |
5 | Marfan | Revised Ghent | After | No | A | 3rd TM | Surgery | NA | 52 SoV; 60 AA; 25 DA | No | No | Cesarean | Yes |
6 | Marfan | Revised Ghent FBN1 | After | No | A | 3rd TM | Surgery | NA | 60 SoV; 68 AA; 22 DA | No | No | Cesarean | Yes |
7 | Marfan | NA | NA | No | A | NA | Surgery | NA | 42 SoV; 50 AA; 24 DA | NA | NA | NA | NA |
8 | BAV | No genetic testing | After | No | A | 3rd TM | Surgery | No | 52 SoV; 46 AA; 24 DA | No | No | Cesarean | No |
9 | BAV | No genetic testing | After | No | A | 3rd TM | Surgery | NA | NA | No | Yes | Cesarean | No |
10 | FTAA | No genetic testing | After | No | A | 2 d PP | Surgery | NA | 60 SoV; 70 AA | No | No | Cesarean | No |
11 | +FH aortic disease | Genetic testing: no variants | NA | No | A | NA | Surgery | 41 SoV | 42 AA; 21 DA | No | Yes | Cesarean | Yes |
12 | None | NA | NA | No | A | 4 d PP | Surgery | NA | 63 SoV; 55 AA; 24 DA | No | No | Vaginal | No |
13 | None | NA | NA | No | A | 3rd TM | Surgery | NA | 47 SoV; 40 AA; 44 DA | NA | Yes | Cesarean | Yes |
14 | Marfan | Ghent FBN1 | Before | No | B | 10 d PP | Medical | NA | 39 SoV; 29 AA; 28 DA | NA | No | Vaginal | Yes |
15 | Marfan | Ghent FBN1 | Before | VSRR | B | 3rd TM | Medical | 20 DA | 35 SoV; 28 AA; 30 DA | Yes | No | Cesarean | Yes |
16 | Marfan | Revised Ghent FBN1 | Before | No | B | 5 d PP | Medical | 22 DA | 28 AA; 27 DA | Yes | No | Vaginal | Yes |
17 | Marfan | Revised Ghent FBN1 | Before | No | B | 1st TM | Surgery | NA | 40 SoV; 60 DA | Yes | Yes | Termination | Yes |
18 | Marfan | Revised Ghent FBN1 | After | No | B | 3rd TM | TEVAR | 36 SoV | 33 SoV; 24 AA; 23 DA | Yes | No | Cesarean | No |
19 | Marfan | Revised Ghent | NA | No | B | 5 d PP | Medical | 41 SoV | 38 SoV | Yes | No | Cesarean | Yes |
29 DA | |||||||||||||
20 | Loeys-Dietz | TGFBR1 | Before | No | B | 56 d PP | Surgery | 42 SoV; 30 AA; 36 DA | 47 SoV; 45 AA; 57 DA | Yes | No | Cesarean | No |
21 | Loeys-Dietz | TGFBR1 | Before | VSRR | B | 3 d PP | Surgery | 28 DA | 33 SoV; 35 AA; 32 DA | Yes | No | Cesarean | No |
22 | +FH aortic disease | Genetic testing: no variants | NA | No | B | 10 d PP | TEVAR | 22 DA | 27 SoV; 30 AA; 30 DA | No | No | Vaginal | Yes |
23 | None | NA | NA | VSRR | B | 3rd TM | Surgery | NA | 35 SoV | NA | NA | Cesarean | NA |
24 | None | Genetic testing: no variants | NA | None | B | 11 d PP | Medical | NA | 27 SoV; 26 AA; 24 DA | No | No | Vaginal | Yes |
25 | None | NA | NA | No | B | 1st TM | TEVAR | NA | 40 SoV; 39 AA; 27 DA | No | Yes | MC | Yes |
26 | None | NA | NA | No | B | 1st TM | Medical | NA | 31 SoV; 34 AA; 24 DA | No | No | Vaginal | No |
27 | None | NA | NA | Prior type B aortic dissection | B | 1st TM | Medical | NA | 24 AA; 29 DA | No | Yes | Termination | NA |
28 | None | NA | NA | No | B | 10 d PP | Medical | NA | 31 SoV; 36 AA; 31 DA | No | Yes, PE | Cesarean | Yes |
29 | None | COL5A1 VUS | NA | No | B | 3rd TM | Medical | NA | 26 SoV; 26 AA; 35 DA | No | No | Vaginal | Yes |
Abbreviations: AA, ascending aorta; BAV, bicuspid aortic valve; DA, descending aorta; +FH, positive family history; FTAA, familial thoracic aortic aneurysm; MC, miscarriage; NA, not available; PE, preeclampsia; PP, post partum; SoV, sinus of Valsalva; TEVAR, thoracic endovascular aortic repair; TM, trimester; VSRR, valve-sparing root replacement; VUS, variant of unknown significance.
Hypertension or hypertensive disorder during pregnancy.