Table 2. Pairwise and Network Meta-analysis for Treatment-Level Comparisons of Depression End-Point Scores (Standardized Mean Differences)^a.

Brief psychoeducation	0.16 (−0.56 to 0.89)	0.00 (−0.40 to 0.40)	0.15 (−0.57 to 0.88)	NA	NA	NA
−0.08 (−0.63 to 0.47)	CBT	−0.12 (−0.95 to 0.71)	−0.01 (−0.76 to 0.75)	−0.26 (−0.80 to 0.28)	0.68 (−0.13 to 1.48)	−0.33 (−0.69 to 0.03)
0.06 (−0.33 to 0.45)	0.14 (−0.38 to 0.66)	Family or conjoint therapy	0.11 (−0.72 to 0.94)	NA	−0.74 (−2.23 to 0.75)	−0.73 (−1.61 to 0.16)
0.06 (−0.55 to 0.66)	0.14 (−0.43 to 0.70)	−0.01 (−0.61 to 0.60)	IPSRT	NA	−0.11 (−0.86 to 0.63)	NA
−0.21 (−0.84 to 0.42)	−0.13 (−0.51 to 0.25)	−0.27 (−0.87 to 0.32)	−0.27 (−0.88 to 0.35)	Psychoeducation	−0.15 (−0.72 to 0.42)	−0.04 (−0.64 to 0.57)
−0.09 (−0.72 to 0.54)	−0.01 (−0.47 to 0.45)	−0.15 (−0.75 to 0.45)	−0.14 (−0.70 to 0.42)	0.12 (−0.33 to 0.57)	Supportive	NA
−0.40 (−0.99 to 0.18)	−0.32 (−0.64 to −0.01)	−0.46 (−1.01 to 0.08)	−0.46 (−1.07 to 0.15)	−0.19 (−0.60 to 0.22)	−0.31 (−0.83 to 0.20)	TAU

Abbreviations: CBT, cognitive behavioral therapy; IPSRT, interpersonal and social rhythm therapy; NA, not available; TAU, treatment as usual.

^aThe lower triangle shows results from network meta-analyses in terms of standardized mean differences for treatment in the column vs treatment in the row. Numbers smaller than 0 favor the column-defining treatment vs the row-defining treatment. Numbers in parentheses indicate 95% CIs. For example, the standardized mean difference for family or conjoint therapy vs TAU is –0.46 (95% CI, –1.01 to 0.08), which favors family or conjoint therapy vs TAU. The upper triangle shows results from pairwise meta-analyses (standardized mean differences) for the treatment in the row vs the treatment in the column (direct evidence). Standardized mean differences smaller than 0 in the upper triangle favor the row-defining treatment vs the column-defining treatment. Some cells are empty (NA) because there were no studies examining the corresponding comparison.