Table 1.

Summary of major miRNAs delivered by chronic lymphocytic leukemia (CLL)-derived exosomes. The table shows for each miRNA the expression levels in CLL-derived exosomes respect to normal circulating exosomes (up ↑ or down ↓) and the target gene or modulated process. The resulted expression levels of target genes are inversely proportional to expression levels of relative miRNA.

miRNA	Expression Level in CLL-Derived Exosomes	Target	Reference
miR-202-3p	↑	Sufu gene	Hegde G.V. et al., MCR 2008 [70]
miR-146a/miR-451	↑	Kinases in Stromal cells	Paggetti J. et al., Blood 2015 [57]
miR-150	↑	Hematopoiesis	Stamatopoulos B. et al., Mol Med 2015 [75]
miR-19b	↑	TP53 and MKI67	Jurj A. et al., Crit Rev Clin Lab Sci. 2018 [80]
miR-155	↑	MDSCs induction	Bruns H. et al., Leukemia 2017 [82]
miR-29	↑	TCL1	Yeh YY. et al., Blood 2015 [55]
miR-223	↓	HSP90B1	Yeh YY. et al., Blood 2015 [55]
Y RNA	↑	Proliferation	Haderk F. et al., Sci Immunol. 2017 [87]