Table 1.
Subtractive proteome analysis and proteins involved in metabolic pathways of selected tick-borne pathogens.
| Step Number | Steps | Borrelia burgdorferi B31 | Ehrlichia chaffeensis Arkansas |
Rickettsia rickettsii Strain “Sheila Smith” |
Anaplasma phagocytophilum HZ | Francisella tularensis SCHU S4 |
|---|---|---|---|---|---|---|
| Host | ||||||
| Homo sapiens | Homo sapiens | Bos taurus | Homo sapiens | Homo sapiens | ||
| 1. | Total proteome | 1391 | 889 | 1246 | 1048 | 1556 |
| 2. | Duplicates (>60% identical) in CD-HIT a | 1181 | 846 | 830 | 712 | 1295 |
| 3. | Non-homologs | 765 | 793 | 409 | 453 | 788 |
| 4. | Essential proteins in DEG b | 34 | 113 | 76 | 105 | 185 |
| 5. | Unique metabolic pathway KEGG c | 13 | 8 | 14 | 6 | 25 |
| 6. | Essential proteins involved KEGG and KAAS d | 12 | 12 | 5 | 8 | 24 |
| 7. | Druggability with cut-off E-value 10−5 | 4 | 3 | 1 | 3 | 4 |
| 8. * | Gut metagenomics with cut-off E-value 10−5 | 2 | 2 | - | 3 | 4 |
* Gut metagenomics were checked for the Homo sapiens host. a CD-HIT: Cluster Database at High Identity with Tolerance against nr database. b DEG: database of essential gene contains essential gene required for survival. c KEGG; Kyota Encyclopedia of genes and genomes contain organism pathways. d KAAS: KEGG Automatic Annotation Server provides functional annotation of genes.