. 2020 Sep 7;7(3):129. doi: 10.3390/vetsci7030129

Table 2.

List of biological and molecular functions, non-host homologous, essential pathways, subcellular localization, druggability, and antigenicity of identified targets.

Name of Protein	NCBI Protein ID	Pathways	KO Number	KEGG ID	Biological Process	Molecular Function	Drug Bank ID	Drug Name	Chemical Formulae	Drug Group	Virulent	Localization	Antigenicity Score	Antigenicity	Allergenicity
Preprotein translocase subunit SecY A. phagocytophilum	WP_011450434.1	Quorum-sensing, A. phagocytophilum HZ	K03076	aph02024	Protein transport, translocation	None predicted evidence	DB06292 DB08907 DB09038	Dapagliflozin Canagliflozin Empagliflozin	C₂₁H₂₅ClO₆ C₂₄H₂₅FO₅S C₂₃H₂₇ClO₇	Approved Approved Approved	Yes	Inner membrane	0.4083	Antigen	Non-allergen
Chromosomal replication initiator protein DnaA. A. phagocytophilum	WP_011450597.1	Two-component system, A. phagocytophilum HZ	K02313	aph02020	DNA replication	DNA-binding	DB00173	Adenine	C₅H₅N₅	Approved, nutraceutical	Yes	Cytoplasmic	0.3982	Non-Antigen	Non-allergen
Aspartate-semialdehyde dehydrogenase A. phagocytophilum	WP_011451356.1	Lysine biosynthesis, A. phagocytophilum HZ	K00133	aph00300	Cellular amino acid biosynthetic process	Oxidoreductase activity	DB00181 DB00996 DB02530	Baclofen Gabapentin gamma-Aminobutyric acid	C₁₀H₁₂ClNO₂ C₉H₁₇NO₂ C₄H₉NO₂	Approved Approved, investigational Approved, investigational	Yes	Outer membrane	0.3987	Non-Antigen	Non-allergen
1UDP-n-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligas B. burgdorferi B31	NP_212438.1	Flagellar assembly, B. burgdorferi B31	K01929	bbu02040	Peptidoglycan biosynthetic process	ATP binding	DB04272	Citric acid	C₆H₈O₇	Approved, nutraceutical, Vet approved	Yes	Cytoplasmic	0.2503	Non-Antigen	Non-allergen
FliS B. burgdorferi B31	NP_212684.1	Flagellar assembly, B. burgdorferi B31	K02422	bbu02040	Bacterial-type flagellum assembly	None predicted evidence	DB00120	l-phenylalanine	C₉H₁₁NO₂	Approved, Investigational, nutraceutical	Yes	Extracellular	0.4200	Antigen	Non-allergen
Twin-arginine translocase subunit TatC Ehrlichia chaffeensis	WP_011452677.1	Bacterial secretion system, Ehrlichia chaffeensis Arkansas	K03118	ech03070	Protein transport by the Tat complex	Protein transmembrane transporter activity	DB01277 DB13173	Mecasermin cerliponase alfa	C₃₃₁H₅₁₈N₉₄O₁₀₁S₇ Not Available	Approved, investigational Approved, investigational	No	Inner membrane	0.8915	Antigen	Non-allergen
Aspartate kinase E. chaffeensis	WP_011452940.1	Monobactam biosynthesis, E. chaffeensis Arkansas	K00928	ech00261	Lysine biosynthetic process via diaminopimelate	Aspartate kinase activity	DB11638	Artenimol	C₁₅H₂₄O₅	Experimental, investigational	Yes	Cytoplasmic	0.5049	Antigen	Non-allergen
Preprotein translocase subunit SecG F. tularensis SCHU S4	YP_169156.1	Quorum sensing, F. tularensis. S4	K03075	ftu02024	Protein secretion	Protein translocase activity	DB00887 DB01016 DB01050 DB04941 DB08820 DB09213 DB09280	Bumetanide Glyburide Ibuprofen Crofelemer Ivacaftor Dexibuprofen Lumacaftor	C₁₇H₂₀N₂O₅S C₂₃H₂₈ClN₃O₅S C₁₃H₁₈O₂ Not Available C₂₄H₂₈N₂O₃ C₁₃H₁₈O₂ C₂₄H₁₈F₂N₂O₅	Approved Approved Approved Approved Approved, investigational Approved, investigational Approved	Yes	Inner membrane	0.7645	Antigen	Non-allergen
UDP-N-acetylmuramate-l-alanine ligase F. tularensis SCHU S4	YP_169292.1	Peptidoglycan biosynthesis, F. tularensis SCHU S4	K01924	ftu00550	Murein biosynthesis	Ligase activity	DB00157 DB09092	NADH Xanthinol	C₂₁H₂₉N₇O₁₄P₂ C₁₃H₂₁N₅O₄	Approved, nutraceutical Approved, withdrawn	Yes	Cytoplasmic	0.4349	Antigen	Non-allergen
Preprotein translocase subunit SecY F. tularensis SCHU S4	YP_169394.1	Quorum sensing, F. tularensis SCHU S4	K03076	ftu02024	Protein transport	None predicted evidence	DB00313; DB05541	Valproic acid brivaracetam	C₈H₁₆O₂ C₁₁H₂₀N₂O₂	Approved, investigational Approved, investigational	Yes	Cytoplasmic	0.6388	Antigen	Non-allergen
UDP-N-acetylmuramoylalanyl-d-glutamate-2,6-diaminopimelate ligase F. tularensis SCHU S4	YP_169464.1	Peptidoglycan biosynthesis, F. tularensis SCHU S4	K01928	ftu00550	Murein biosynthesis	Ligase activity	DB11638	Artenimol	C₁₅H₂₄O₅	Experimental, investigational	Yes	Inner membrane	0.3851	Non-antigen	Non-allergen
Cytochrome d ubiquinol oxidase subunit II- R. rickettsii Sheila Smith	WP_012150506.1	Two-component system, R. rickettsii “Sheila Smith”	K00426	rri02020	Oxidation-reduction process	None predicted evidence	DB01221	Ketamine	C₁₃H₁₆ClNO	Approved, vet approved	Yes	Inner membrane	0.6850	Antigen	Non-allergen