Table 1.
No | Process | Voltage (kV) | Flow Rate (mL/h) | Morphology/Structure a | Drug Loading in the NPs (w/w%) b | |
---|---|---|---|---|---|---|
Core Fluid | Shell Fluid | |||||
E1 | Single-fluid | 16 | 1.0 | Irregular/Monolithic | 23.1% | |
E2 | Modified coaxial | 18 | 1.0 | 0.3 | Round/Core-shell | 22.1% |
a The morphology and structure are experimental results. b The drug loading in the nanoparticles (NPs) (w/w%) is a theoretical value calculated according to the electrospraying conditions. Because electrospraying is essentially a physical drying process and tamoxifen citrate (TAM) has a boiling point of 140–144 °C without sublimation property, the drug encapsulation efficiency can be regarded as 100% [27,46].