Figure 4.

pEYS611 maintains retinal function in the rat LID model. Rats received a single ciliary muscle electrotransfection of pEYS611 at the dose of 0.3, 3, or 30 µg/eye on D-3 or left untreated (n = 8 animals/group). Except for unexposed animals (no LID), retinal degeneration was induced on D0 by 24 h of bright light exposure (6500 lux). Dark- and light-adapted ERG responses were recorded simultaneously from both eyes on D8. (A,B) Average amplitude (µV) of scotopic a-and b-waves from ERG responses elicited by a stimulus intensity of 3 cd·s/m² and (C) amplitude of photopic b-wave from ERG responses elicited by a stimulus intensity of 10 cd·s/m² are presented as mean ± sem. * p < 0.05; **** p < 0.0001 using a repeated measure mixed model and determination of confidence intervals versus LID/untreated group.