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Schematic diagram of the pathway involved in the hepatic de novo biosynthesis of triglycerides.
Chol: total cholesterol; HMG CoA R: 3-hydroxy-3-methylglutaryl CoA reductase; SREBP-1: sterol regulatory element-binding proteins1; SREBP-2: sterol regulatory element-binding proteins 2; SCD-1: stearoyl-CoA desaturase; TG: triglycerides; HIF-1α: hypoxia-induced factor-1α.
