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. 2020 Sep 8;9(9):585. doi: 10.3390/antibiotics9090585

Figure 1.

Figure 1

Cytokine production by A549 cells stimulated with purified P. aeruginosa LPS (a,b) or whole P. aeruginosa (c) in the presence of lin-SB056-1 and/or its dendrimeric derivative for 4 h (37 °C, 5% CO2). Production of IL-8 (a) and IL-6 (b) by A549 cells stimulated with LPS (800 ng/mL) in the presence of lin-SB056-1 and (lin-SB056-1)2-K. (c) production of IL-6 and IL-8 by A549 cells stimulated with P. aeruginosa PAO1 (fixed with 4% paraformaldehyde; 5 × 106 CFU/well) in the presence of (lin-SB056-1)2-K. LPS: LPS-stimulated A549 cells without peptide treatment. PAO1: P. aeruginosa-stimulated A549 cells without peptide treatment. Data are reported as mean ± standard error of the mean (SEM) of at least three independent experiments. * p < 0.05, *** p < 0.001 compared to the peptide-untreated control (one-way ANOVA for paired samples followed by Tukey–Kramer post-hoc test).