Table 4.
List of most significantly modulated canonical pathways due to I/R.
| Canonical Pathways | −log(p-Value) | Changes | Molecules | |
|---|---|---|---|---|
| Mitochondrial Homeostasis and Function | Ketogenesis | 3.62 | Downregulated | HADHA, HMGCL |
| Protein Ubiquitination Pathway | 1.7 | Upregulated | HSPA1L, PSMD13, USO1 | |
| Leucine Degradation I | 1.72 | Downregulated | HMGCL | |
| Ketolysis | 1.68 | Downregulated | HADHA | |
| Neuronal Calcium Dysregulation | Calcium Transport I | 1.68 | Upregulated | ATP2B2 |
| Cytotoxicity Regulation | Formaldehyde Oxidation II (Glutathione-dependent) | 2.37 | Downregulated | ESD |
| Anandamide Degradation | 2.2 | Upregulated | FAAH | |
| Purine Ribonucleosides Degradation to Ribose-1-phosphate | 1.83 | Downregulated | PNP | |
| Reactive Oxygen Species (ROS) Scavenging | Heme Degradation | 2.07 | Upregulated | BLVRA |
| Vitamin-C Transport | 1.31 | Downregulated | SLC2A1 | |
| Neural Transduction | Phototransduction Pathway | 2.25 | Downregulated | CNGA1, GNGT1 |
| GABA Receptor Signaling | 1.76 | Upregulated | AP2M1, SLC32A1 | |
| Vascular Function | eNOS Signaling | 1.35 | Downregulated | CNGA1, HSPA1L |
| Protein Kinase A Signaling | 1.29 | Upregulated | ACP1, CAMK2B, CNGA1 |
I/R vs. CTRL.