Table 5.
Clustered overview of H2S regulated canonical pathways. (A) The canonical pathways restored by H2S. (B) The canonical pathways regulated by H2S comparing to CTRL.
| Canonical Pathways | −log(p-Value) | Changes | Molecules | |
|---|---|---|---|---|
| Mitochondrial Homeostasis and Function | Ketogenesis | 3.78 | Upregulated | HADHA, HMGCL |
| Leucine Degradation I | 1.8 | Upregulated | HMGCL | |
| Ketolysis | 1.76 | Upregulated | HADHA | |
| Neural Transduction | GABA Receptor Signaling | 1.91 | Downregulated | AP2M1, SLC32A1 |
| ROS Regulation | Vitamin-C Transport | 1.38 | Upregulated | SLC2A1 |
| HIF1α Signaling | 0.742 | Upregulated | SLC2A1 | |
| Canonical Pathways | −log(p-Value) | Changes | Molecules | |
| NER pathway | 1.18 | Upregulated | COPS6 | |
| Oxidative Phosphorylation | 1.16 | Downregulated | NDUFA5 | |
| Estrogen Receptor Signaling | 1.04 | Upregulated | DDX5 | |
| Corticotropin Releasing Hormone Signaling | 1.02 | - | KRT1 | |
| Phagosome Maturation | 0.708 | - | DYNLRB1 | |
(A) H2S vs. I/R. (B) H2S vs. CTRL.