Table 2.

Model performance in the test data-set

Time	Outcome	Model	AUC	Accuracy	Sensitivity	Specificity	PPV	NPV
Week 6	Response	Baseline	0.60	0.59	0.67	0.51	0.59	0.59
		Total improvement	0.73	0.70	0.81	0.59	0.67	0.74
		Item improvement	0.77	0.70	0.74	0.66	0.70	0.71
		Item interactions	0.77	0.70	0.72	0.67	0.70	0.70
	Remission	Baseline	0.64	0.68	0.09	0.98	0.69	0.68
		Total improvement	0.74	0.71	0.30	0.92	0.64	0.72
		Item improvement	0.78	0.74	0.44	0.89	0.66	0.76
		Item interactions	0.78	0.74	0.43	0.89	0.66	0.76
Week 12	Response	Baseline	0.62	0.69	1.00	0.00	0.69	N/A
		Total improvement	0.67	0.72	0.93	0.27	0.73	0.62
		Item improvement	0.71	0.71	0.90	0.29	0.73	0.57
		Item interactions	0.70	0.70	0.90	0.29	0.73	0.56
	Remission	Baseline	0.62	0.59	0.61	0.57	0.60	0.58
		Total improvement	0.68	0.64	0.69	0.59	0.64	0.64
		Item improvement	0.74	0.67	0.69	0.64	0.67	0.66
		Item interactions	0.73	0.66	0.65	0.68	0.68	0.65

AUC, area under the (receiver operating characteristic) curve; N/A, not applicable (undefined); NPV, negative predictive value; PPV, positive predictive value.