Table 3.

Prognostic factors associated with DSS in AM patients.

Parameter	Univariate analysis		Multivariate analysis
	Hazard ratio (95% CI)	p value	Hazard ratio (95% CI)	p value
Age (years)		0.08
≤60 (N = 166)	0.68 (0.43–1.05)
>60 (N = 176)	1.0
Gender		0.001		0.011
Male (N = 187)	2.21 (1.38–3.55)		1.99 (1.17–3.38)
Female (N = 155)	1.0		1.0
Chinese vs. Caucasian		0.56
Chinese (n = 280)	1.26 (0.58–2.76)
Caucasian (n = 62)	1.0
Pathologic stage		<0.001
0/I (n = 81)	0.08 (0.03–0.27)
II (n = 171)	0.42 (0.27–0.66)
III (n = 89)	1.0
Location		0.69
Volar (n = 230)	0.91 (0.57–1.46)
Subungual (n = 112)	1.0
Breslow thickness (mm)	1.06 (1.03–1.09)	<0.001	1.05 (1.01–1.09)	0.018
Clark Level (%)		<0.001
Unknown (n = 91)	0.42 (0.23–0.77)
I/II/III (n = 68)	0.26 (0.11–0.60)
IV/V (n = 183)	1.0
Histology		0.93
Nodular (n = 9)	1.01 (0.25–4.12)
Superficial spreading (n = 12)	0.81 (0.25–2.57)
Acral lentiginous (n = 321)	1.0
Ulceration
Yes (n = 203)	4.06 (2.20–6.57)	<0.001	3.39 (1.20–8.23)	0.026
No (n = 130)	1.0		1.0
SLN biopsy status		<0.001		0.003
Positive (n = 97)	3.45 (2.19–5.45)		4.10 (1.54–10.92)
Negative (n = 217)	1.0		1.0
Surgery		0.88
Amputation (n = 115)	1.04 (0.64–1.68)
WLE (n = 203)	1.0
Adjuvant therapy		0.60
Yes (n = 242)	0.87 (0.51–1.47)
No (n = 90)	1.0