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. 2020 May 18;27(11):3021–3036. doi: 10.1038/s41418-020-0558-4

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© The Author(s), under exclusive licence to ADMC Associazione Differenziamento e Morte Cellulare 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Kaplan–Meier curves showing differences in the overall survival of patients stratified according to their mRNA expression levels of LOX family members using the best expression cutoff (n = 154, log-rank test). b LOXL1 and LOXL4 mRNA expression levels in tumors and paired tissues (n = 21, paired t test, two-tailed). c IHC staining of the LOXL1 and LOXL4 proteins in tumor and paired tissues (Scale bar, 100 µm). d LOXL1 and LOXL4 mRNA expression in tissues from patients with or without recurrence. 21 glioma samples were divided into two groups: recurrence (+, n = 16) or nonrecurrence (-, n = 5) (means ± SD, unpaired t test, two-tailed). e LOXL1 and LOXL4 mRNA expression in tissues from patients with LGG and GBM. LGG: low grade glioma (LGG, n = 21; GBM, n = 21; means ± SD, unpaired t test, two-tailed). f Colony formation assays of U87-Vec, U87-LOXL1, LN18-shNT and LN18-shLOXL1 cells (the data are presented means ± SD, unpaired t test, two-tailed). g–i The proliferation and percentages of surviving and apoptotic U87-Vec, U87-LOXL1, LN18-shNT and LN18-shLOXL1 cells cultured under 3D conditions were examined (means ± SD, unpaired t test, two-tailed). j, k Colony formation and apoptotic assay were performed after depletion of LOXL1 in GSC11 cells.