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. 2020 Oct 14;10:17293. doi: 10.1038/s41598-020-74195-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The effect of LRRK2 kinase inhibition on constitutive LRRK2 Ser955 and Ser973 phosphorylation sites. (A) Representative western blot of LRRK2 G2019S patient-derived LCLs treated for 24 h with Compound RA283. (B) Quantification of western blots demonstrated that Compound RA283 decreased LRRK2 pSer955 levels at all doses tested. (C) Representative western blots of LRRK2 G2019S patient-derived LCLs treated for 24 h with Compound RA283. White space represents where sections of the blot were removed for clarity. (D) Quantification of western blots demonstrated that Compound RA283 decreased LRRK2 pSer973 levels at all doses tested. Data are mean ± SEM. (*p < 0.001, determined by one-way ANOVA with a Tukey’s post-hoc comparison). n = 3 (ND00011 and ND00264) technical replicates for panels A and B; n = 2 (ND00011 and ND00264) plus n = 1 (ND02559 and ND01618) technical replicates for (C,D). Full blots available in Supplemental Figs. S11, S12, and 13.