Table 1.
MIC (minimum inhibitory concentration) range, MIC50, MIC90 and percentage of resistant Pasteurella multocida isolates recovered in Spain between 2017 and 2019.
| Antimicrobial Agent | Range (μg/mL) | MIC50 (μg/mL) | MIC90 (μg/mL) | Breakpoint (μg/mL) * | Antimicrobial Resistance (%) |
|---|---|---|---|---|---|
| Amoxicillin | 1–8 | 0.25 | 8 | 0.5 $ | 2.1 |
| Ceftiofur | 0.06–0.25 | 0.06 | 0.12 | 2 | 0 |
| Doxycycline | 0.25–2 | 1 | >2 | 0.5 $$ | 52.1 |
| Enrofloxacin | 0.03–0.5 | 0.03 | 0.12 | 0.25 | 2.1 |
| Florfenicol | 0.5 | 0.5 | 0.5 | 2 | 0 |
| Marbofloxacin | 0.03–0.5 | 0.03 | 0.12 | 0.25 & | 4.2 |
| Oxytetracycline | 0.5–8 | 2 | >8 | 0.5 | 68.7 |
| Sulphamethoxazole/trimethoprim (19/1 ratio) § | 0.06–4 | 0.25 | >4 | 0.5 && 2 §§ |
43.7 31.2 |
| Tiamulin | 2–32 | 16 | >32 | 16 | 25 |
| Tildipirosin | 0.5–4 | 1 | 4 | 4 | 0 |
| Tilmicosin | 2–32 | 8 | 32 | 16 | 2.1 |
| Tulathromycin | 0.5–4 | 1 | 2 | 16 | 0 |
* Clinical breakpoints were obtained from CLSI VET08 or CLSI M100 with the following clarifications: $ extrapolated from ampicillin. $$ Extrapolated from tetracycline. & Extrapolated from enrofloxacin. && Extrapolated from Streptococcus suis. § MIC is for trimethoprim in this table. §§ Extrapolated from Staphylococus hyicus and Escherichia coli.