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. 2020 Oct 14;10:17178. doi: 10.1038/s41598-020-73989-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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IL-26 exerts effects on moDCs via TLR2. (a) Secreted embryonic alkaline phosphatase (SEAP) reporter assay was used to determine if IL-26 is able to signal via TLR2 (n = 4). (b) HEK Null1 cells are the parental cell line and are used as controls (n = 3). Statistical analysis was done using Mann Whitney U test (* equals p < 0.05). (c) TNF-α and IL-6 secretion in THP1 macrophages treated with siTLR2 or control siRNA (siCTL) (n = 2). (d) TNF-α secretion by THP1 macrophages, primary macrophages and moDCs treated with IL-26 or pretreated with anti-TLR2-antibody for 45 min before the addition of IL-26 for another 24 h and measured via ELISA (n = 6). (e) TLR2 gene expression after IL-26 stimulation in THP1 macrophages, primary macrophages and DCs (n = 5), or comparing tuberculosis (f) or sarcoidosis (g) to their respective healthy control. Data are presented as mean + SEM or a single dot is representing one independent sample. Statistical analysis was done using Wilcoxon matched pairs signed rank test (* equals p < 0.05) or Mann–Whitney U test for the diseases (*** equals p < 0.001).