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(A) Correlation of the in vitro cumulative amount of NIA permeated through human skin (4 ≥ n ≥ 3; mean ± SEM) and the in vivo amount of NIA inside the skin at 2 μm after the 60 min application of formulations (n = 8; mean ± SEM). (B) Correlation of the in vitro cumulative amount of NIA permeated through human skin (4 ≥ n ≥ 3; mean ± SEM) and the in vivo concentration of NIA inside the skin (mg/cm3) at 2 μm after the 60 min application of formulations (n = 8; mean ± SEM).
