Table 2.
Physicochemical properties of blank and berberine (BER)-containing liposomes.
| Liposomes (75:40:5 mM) |
Mean Diameter (nm) | PDi | Z-Potential (mV) | BER EE (%) | nmol BER/ μmol lipid |
|---|---|---|---|---|---|
| PC:Chol:TS | 133.8 ± 1.4 | 0.19 | −22 ± 1 | – | – |
| PC:Chol:TS-BER | 121.6 ± 1.3 | 0.25 | −38 ± 1 | 14.1 ± 2.9 | 6.6 ± 1.8 |
| PC:Chol:DDAB | 159.6 ± 0.9 | 0.27 | 52 ± 1 | – | – |
| PC:Chol:DDAB-BER | 151.4 ± 0.8 | 0.27 | 58 ± 3 | 2.1 | 1.3 |
| PC:Chol:DP | 195.4 ± 4.8 | 0.28 | −47 ± 1 | – | – |
| PC:Chol:DP-BER | 245.2 ± 2.3 | 0.21 | −46 ± 1 | 28.7 ± 1.4 | 17.9 ± 3.8 |
Abbreviations: PDi—polydispersity index; EE—encapsulation efficiency; PC—soybean phosphatidylcholine; Chol—cholesterol; TS—d-α-tocopherol succinate; DP—dicetyl phosphate; DDAB—didodecyldimethylammonium bromide.