Table 2.
Advantages | Disadvantages |
---|---|
High yield | N or O-linked glycosylation pattern (different from higher eukaryote) Hypermannosylation Proteolytic degradation |
Stable production strains | |
Durability | |
Cost-effective | |
High-density growth | |
High productivity | |
Suitable for isotopically labeled protein production | |
Rapid growth in chemically defined media | |
Product processing similar to mammalian cells | |
Can handle S–S-rich proteins | |
Can assist in protein folding | |
Can glycosylate proteins |