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. 2020 Oct 7;37:101747. doi: 10.1016/j.redox.2020.101747

Fig. 2.

Fig. 2

METRNL overexpression alleviates DOX-induced cardiotoxicity in mice. (A) Schematic protocol for AAV9 and DOX treatment. (B) Serum levels of LDH, cTnT and CK-MB in mice with or without METRNL overexpression after DOX injection (n = 8). (C–E) Hemodynamic and echocardiographic parameters of cardiac function (n = 8). (F) Statistical data of HW/TL (n = 8). (G) The survival curves up to 9 weeks after the first DOX injection in mice with or without METRNL overexpression (n = 20). Values represent the mean ± SD. *P < 0.05 versus NS + Ctrl, #P < 0.05 versus DOX + Ctrl.