Fig. 6.

METRNL exerts the cardioprotective effects via activating SIRT1 in vivo. (A) Cardiac SIRT1 protein abundance and statistical results (n = 6). (B) Cardiac SIRT1 activity (n = 8). (C) The levels of MDA and 3-NT in heart samples (n = 6–8). (D) Quantification of RUNEL-positive nuclei in heart tissues (n = 8). (E) Serum levels of LDH, cTnT and CK-MB in mice (n = 8). (F–G) Hemodynamic and echocardiographic parameters (n = 8). Values represent the mean ± SD. *P < 0.05 versus the matched group. In Fig. 6A and B, *P < 0.05 versus NS + Ctrl, ^#P < 0.05 versus DOX + Ctrl. NS indicates no significance.