Table 2.

In-vitro ^a data of the MTT cell proliferation assay for the bumetanide compounds.

Compound	A-498 IC50 (μM) b	SCaBER IC50 (μM) b
Acetazolamide	40.00 ± 0.37	40.63 ± 0.36
8a	15.66 ± 0.63	28.36 ± 1.4
8h	6.55 ± 0.26	78.04 ± 0.29
9b	16.08 ± 1.4	78.07 ± 1.7
9c	5.07 ± 0.11	8.80 ± 1.9

^a In-vitro data are reported from three replicate experiments ±SEM. ^b IC₅₀ values represent the effective concentration of a given compound for exhibiting 50% inhibitory response of that compound’s intrinsic maximum response.