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Schematic illustration of function of NBCn1 as a migration machinery and regulatory factors on NBCn1-mediated migration in lung cancer cells. IRBIT protein is recruited to NBCn1, plays a positive role in the migration of lung cancer cells and stored expression of NBCn1 in the plasma membrane as a stimulated condition with EGF. NBC inhibitor S0859, knockdown of NBCn1 or IRBIT, CaMKII inhibitor KN93 attenuate the NBCn1-mediated cellular migration.
