Figure 10.

Periplasmic Cu chaperones and their target cuproproteins. The structures of Cu-chaperones are shown in the left and their corresponding target proteins in the right panels. The respective Cu binding sites are indicated, and Cu ions are shown in cyan. The ScoI-homologue SenC and Cox11 contain a single transmembrane domain of unknown structure indicated by a yellow box. NosZ, which was crystallized as homodimer, contains two Cu binding sites; for the Cu_A center, PccA/PCu_AC and SenC/Sco1 are required, while NosL is involved in the formation of the Cu_Z center. Structures were retrieved from the protein database (PDB) with the following IDs: 4WBR (ScoI/SenC), 2K70 (PCu_AC/PccA), 1SP0 (Cox11), 2HQ3 (NosL), 6WIS (CopG), 4GQZ (CueP), 5DJQ (cbb₃-Cox), 3FYE (aa₃-Cox), 6RZK (NosZ), 3OD3 (CueO), 1EQW (Cu/Zn SOD), and depicted using Pymol.