Table 3.
Cu affinities of bacterial Cu-chaperones and metal-binding sites (MBS) of P1B-type ATPases. N-MBS refers to the N-terminal MBS and TM-MBS to the membrane-integral MBS of P1B-type ATPases. Bacterial P1B-type ATPases often have two N-MBS.
| Protein/Organism | Affinity for Cu(I) (Kd, M) | Reference |
|---|---|---|
| CopZ (B. subtilis) | 6 × 10−22 | [189] |
| N-MBS1 (E. coli) | 7 × 10−19 | [189] |
| N-MBS2 (E. coli) | 3 × 10−18 | [189] |
| TM-MBS1 (A. fulgidus) | 1 × 10−15 | [190] |
| TM-MBS2 (A. fulgidus) | 1 × 10−15 | [190] |
| CusF (E. coli) | 5 × 10−11 | [191] |
| PccA (R. capsulatus) | 8 × 10−16 | [47] |
| SenC (R. capsulatus) | 3 × 10−15 | [47] |