Table 10.

Compounds that enhance AD prognosis and inhibit CD4+ Th17.

Molecule	Effect on Th17/Treg Axis	Effect on AD
Triptolide	Inhibit Th17 cells [85]	Potential candidate for drug [86].
Caffeine (1,3,7-Trimethylpurine-2,6-dione)	Favors autoimmunity Treg and decreases cytokines needed for Th17 and Th1	Improve prognosis [87]
Albumin	Albumin functions as an inhibitor of T cell adhesion in vitro. Negatively correlated with Th17, positively correlated with Treg	Improve prognosis
Huperzine A	reduce lymphocyte proliferation and the secretion of proinflammatory cytokines	Choline esterase inhibitor
Insulin	Increase Treg	Improve prognosis
Ladostigil	reduce lymphocyte proliferation and the secretion of proinflammatory cytokines	a cholinesterase and monoamine oxidase inhibitor
Quercetin	Immunosuppressive, inhibit Th17	Improve prognosis