Table 1.
The minimum inhibitory concentrations (MICs) of fosfomycin for 129 clinical isolates of carbapenem-resistant Enterobacterales.
| Carbapenem-Resistant Enterobacterales Isolates | Number of Isolates | Fosfomycin MICs (mg/L) | % of Isolates | |||
|---|---|---|---|---|---|---|
| CLSI a | EUCAST b | |||||
| MIC50 | MIC90 | MICs Range | S/I/R | S/R | ||
| Klebsiella pneumoniae | 116 | 64 | >1024 | 0.38 to >1024 | - | 40.52/59.48 |
| Escherichia coli | 12 | NA c | NA c | 1 to 16 | 100/0/0 | 100/0 |
| Enterobacter cloacae | 1 | NA c | NA c | 12 | - | 100/0 |
| All isolates | 129 | 48 | >1024 | 0.38 to >1024 | - | 46.51/53.49 |
MICs = minimum inhibitory concentrations; MIC50 = MIC for 50% of clinical isolates; MIC90 = MIC for 90% of clinical isolates; CLSI = Clinical and Laboratory Standards Institute; EUCAST = European Committee on Antimicrobial Susceptibility Testing; - = no breakpoint criteria for interpretation; NA = not available data. a CLSI breakpoints for Escherichia coli urinary isolates, MIC ≤ 64 mg/L as susceptible (S), MIC =128 mg/L as intermediate (I), and MIC ≥ 256 mg/L as resistant (R). b EUCAST breakpoints for Enterobacterales spp. isolates, MIC ≤ 32 mg/L as susceptible (S), and MIC > 32 mg/L as resistant (R). c the small numbers of clinical isolates.