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Half-life (t1/2), intrinsic clearance (Clint), hepatic clearance (Clhep), and hepatic extraction ratio values of DWP16001 in human, dog, monkey, mouse, and rat hepatocytes.
| Parameters | Human | Dog | Monkey | Mouse | Rat |
|---|---|---|---|---|---|
| t1/2 (min) | 866.3 | 223.5 | 165.0 | 533.1 | 990.0 |
| Clint (mL/min/kg) | 5.7 | 42.7 | 32.3 | 61.4 | 9.8 |
| Clhep (mL/min/kg) | 4.5 | 17.9 | 18.5 | 36.5 | 8.3 |
| Hepatic extraction ratio | 0.22 | 0.56 | 0.43 | 0.41 | 0.15 |
