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. 2020 Oct 15;15:290. doi: 10.1186/s13023-020-01569-4

Fig. 3.

Fig. 3

Genotype–phenotype correlations. a The combined group of HI and DN Cys led to aortic involvement significantly more frequently than DN non-Cys genetic variants. b The need for aortic surgery was significantly more common for DN Cys mutations than for the other two types. c Individuals with detected mutations showed a significantly higher aortic involvement rate than individuals without an identified (likely) pathogenic variant. No difference could be observed between MFS and LDS patients