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. 2020 Oct 1;11:584310. doi: 10.3389/fimmu.2020.584310

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Copyright © 2020 Xu, Yang, Wang and Nayak.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of the AM gene expression patterns in Scgb1a1 KO and WT mice. (A) Up-regulated and down-regulated genes in AMs at 4, 8, 12, and 40 weeks; (B–E). Volcano plots of significantly up-regulated (red) and down-regulated (blue) genes (FDR < 0.05); (F) PCA plot of the variant feature of gene expression; (G) Venn diagrams of the significantly changed genes. Venn diagrams of the significantly changed gene sets in AMs from KO vs WT mice at different ages including GO-Molecular function pathways (H), GO-Biological process pathways (I), KEGG-metabolism pathways (J), and KEGG-Disease pathways (K). FDR < 0.05 was considered significant; FC, fold change.