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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Biochim Biophys Acta Mol Cell Res. 2020 Aug 21;1867(12):118825. doi: 10.1016/j.bbamcr.2020.118825

Figure 3: Hallmark events of the ERSU checkpoint.

Figure 3:

Under ER stress, the cortical ER (cER) visualized by HMG1-GFP reporter is blocked from entering the daughter cell. The septin ring, visualized by CDC11-GFP, moves away from the bud neck. These events result in cytokinesis block. In ERSU-deficient slt2Δ cells, the cER enters into the daughter cell and the septin ring stays at the bud neck even under ER stress. The inability to induce the ERSU pathway in response to ER stress ultimately results in cell death.