In vitro cytotoxicity evaluation of the A. melanocarpa (Michx.) Elliott. Extract (free or encapsulated in the silica-type matrices) and of the MCM-41 silica-type supports (10, 50, 100, and 250 µg/mL) on the A375 human melanoma cell line at 24, 48, and 72 h post-treatment by means of an MTT assay. The results are expressed as cell viability percentage (%) related to the control (i.e., the untreated cells). The data represent the mean values ± standard deviation (SD) of three independent experiments. One-way analysis of variance (ANOVA) followed by a Dunnett’s multiple comparison test was used for comparison among groups (* p < 0.05; ** p < 0.01; *** p < 0.001).