Table 1.

Characteristics of the studies included

Study, year	Design	Inclusion Criteria	Outcomes	Atosiban dose
Moraloglu et al., 2010	Prospective, randomized, placebo-controlled clinical study	Women undergoing intracytoplasmic sperm injection who had top-quality embryos	Clinical pregnancy rate per cycle and implantation rate	Intravenous atosiban 30 min before the embryo transfer with a bolus dose of 6.75 mg, and the infusion was continued with an infusion rate of 18 mg/h. After performing embryo transfer, the dose of atosiban was reduced to 6 mg/h and the infusion was continued for 2 h (total administered dose: 37.5 mg).
Chou et al., 2011	Retrospective cohort study	Repeated implantation failure (RIF)	Implantation rate, clinical pregnancy rate, live birth rate	Forty patients received a single bolus dose (6.75 mg, 0.9 mL/vial) of atosiban before ET (Group 2), and 30 patients received a bolus dose of 6.75 mg atosiban followed by infusion at 18 mg/hr. for 3 hours immediately after ET (Group 3).
Lan et al., 2012	Prospective cohort study	Women with repeated implantation failure	Uterine contraction, implantation rate (IR) and clinical pregnancy rate (CPR)	I.V. bolus of 6.75 mg at 30 min prior to embryo transfer followed by i.v. infusion at a rate of 18 mg/h for 1h and 6 mg/h for the subsequent 2h. The total dose administered was 36.75 mg.
Ng et al., 2014	Multi-center randomized double blind study	Consecutive subfertile women undergoing IVF treatment	The primary outcome measure was the live birth rate and the secondary outcome measures including positive pregnancy test, clinical pregnancy, ongoing pregnancy, miscarriage, multiple pregnancy and ectopic pregnancy rates.	I.V. Atosiban 30 min before the transfer with a bolus dose of 6.75 mg, and the infusion was continued at a rate of 18 mg/h for 1h. The dose of Atosiban was then reduced to 6 mg/h after embryo transfer and the infusion was continued for another 2h. Therefore, the total administered dose was 37.5 mg.
He et al., 2016a	Randomized, controlled clinical trial.	Women with endometriosis undergoing frozen–thawed embryo transfer	Implantation rate and pregnancy rate.	IV bolus of 6.75 mg at approximately 30 min before ET.
He et al., 2016b	Prospective cohort study	Patients undergoing IVF/ET using cryopreserved embryos	Uterine contraction, clinical pregnancy rate	I.V. bolus of 6.75 mg at about 30 min prior before ET.
Hebisha et al., 2016	Randomized controlled trial.	One hundred and eighty two women, prepared for intracytoplasmic sperm injection for male or tubal factor infertility, using long agonist protocol	Pregnancy rate, implantation rate.	7.5 mg Atosiban by slow IV injection