Table 1.

Cellulose/collagen dressing for DFU.

Author	Aim	Study Design	Sample Size	Follow Up	Findings	Conclusion
Manizate and co-workers (2012) [55]	Compare the efficiency of bovine native collagen with silver ion (Ag) and sodium carboxymethylcellulose with Ag	Comparative, post-market clinical evaluation	10 patients	1st and 4th week	-50% of the wound exhibit S. Aureus -By the 4th week, the bacteria load increases up to 1.53 × 105 ppm	-Bovine native collagen dressing shows rapid wound closure.
Gottrup and co-workers (2013) [68]	Compare collagen/oxidised regenerated cellulose (ORC)/silver therapy to standard treatment	Randomized control trial	39 patients	Every 2 week for 14 weeks	-Decreased concentration of elastase, MMP-9 -low MMP-9:TIMP-1 concentration -Absence of infection and adverse effects	-Collagen/ORC/silver therapy shows improved wound healing.
Ulrich and co-workers (2011) [43]	Evaluate the effect of collagen matrix/oxidized regenerated cellulose in wound exudate of DFU patients	Comparative clinical study	32 patients	14th, 28th, 42th, and 56th day	-Reduced level of MMP-2 -Reduction in plasmin, elastase and gelatinase	-Wound size reduction on 14th and 28th days in ORC treated groups.
Griffin and co-workers (2019) [69]	Comparative study between the effectiveness of oxidized regenerated cellulose and ovine collagen extracellular matrix	Comparative study	3230 patients	4th, 8th, 12th, and 16th week	-82% of the healed wound with ORC dressing -15.2% of a worsened wound with ovine collagen extracellular matrix dressing	-ORC decreases healing duration by improving granulation tissue formation in a short period.
Dumont and co-workers (2018) [61]	Evaluate the effectiveness of collagen-based dressing for DFU patients	Clinical follow-up	6 male & 1 female	38th to 64th day	-Increased formation of granulation tissue -complete surface healing at the wound site	-Fast skin restoration -Decreased healing tine. -Decreased rate of infection.
Kloeters and co-workers (2015) [62]	Evaluate the effectiveness of oxidized regenerated collagen-cellulose matrix in pressure ulcer	Clinical assessment	33 patients	Weekly for 12 weeks	-Decreased level of plasmin and elastase activity -reduction in the surface area of the wound -Absence of infection and intolerance towards oxidized regenerated cellulose/collagen matrix dressing.	-Notable fast healing rate.
Solway and co-workers (2011) [65]	Study the effectiveness of microbial cellulose in DFU	Parallel open-label trial	34 patients	Weekly till complete wound closure	-Increased formation of granulation tissue and maintenance of moist environment at the wound area -High tensile strength and crystallinity of the microbial cellulose	-Rapid wound healing with a short period of re epithelisation
Li and co-workers (2020) [72]	Access the efficiency of naturally occurring bacterial cellulose-hyper branched cationic polysaccharide derivative on wound healing of diabetic rats	In vivo study	Not specified	1st, 4th and 7th day	-Good viability of cell -Low concentration of LDH -No effect on apoptosis -Inhibition in MMP-9	-Increased wound healing rate.
Song and co-workers (2018) [63]	Evaluate the effect of Selenium-loaded cellulose film in diabetic induced rats	In vivo study	48 male rats	3rd and 12th day	-Low elongation, high tensile strength, excellent microporous structure and high-water absorption capacity -Absence of toxicity	-Notable rapid wound healing. -Notable stimulation in the angiogenesis pathway.
Li and co-workers (2020) [64]	Evaluate the effectiveness of carboxymethyl cellulose/K-carrageena/graphene oxide/konjac glucomannan hydrogel in diabetic induced mice	In vitro and in vivo study	18 mice	4th, 7th, 14th and 21st day	-The presence of permeable surface, high mechanical strength and great swelling capacity, supports the viability of the cell and has bactericidal property.	-Notable rapid wound recuperating. -Advanced fibroblast production and rapid re-epithelialization were seen.