Skip to main content
. 2020 Aug 27;10(9):202. doi: 10.3390/membranes10090202

Table 3.

List of highly lipophilic, electrochemically active analytes (antidepressant drugs) with sub-micromolar therapeutic concentration ranges as potential targets for the development of voltammetric methods based on organic film-coated working electrodes. The log p values are generally from DRUGBANK (www.drugbank.ca). Experimentally determined values are provided with the source. SSRI stands for selective serotonin reuptake inhibitors.

Sertraline
(Zoloft)
Antidepressant
SSRI 		graphic file with name membranes-10-00202-i001.jpg log P = 5.06–5.15
MW: 306.229 g/mol
Concentration range:
30–200 ng/mL
0.1–0.65 µmol/L
Amitriptyline
(Elavil)
Antidepressant		 graphic file with name membranes-10-00202-i002.jpg log P = 4.81–5.1
log Pexp = 4.92 [42]
MW: 277.403 g/mol
Concentration range:
75–175 µg/L
0.27–0.63 µmol/L
Aripiprazole (Abilify)
Antipsychotic		 graphic file with name membranes-10-00202-i003.jpg log P = 4.9–5.21
MW: 448.385 g/mol
Concentration range:
150 and 300 ng/mL
0.33–0.67 µmol/L
Sirolimus
(Rapamycin)
Immunosuppressant		 graphic file with name membranes-10-00202-i004.jpg log P = 4.8–7. 5
MW: 914.2 g/mol
Concentration range:
4–20 ng/mL
4.4–21.9 nmol/L
Everolimus
(Zortress)
Immunosuppressant		 graphic file with name membranes-10-00202-i005.jpg log P = 5.0–7.4
MW: 958.240 g/mol
Concentration range:
3–8 ng/mL
3.1–8.3 nmol/L
Citalopram
(Celexa)
Antidepressant
SSRI		 graphic file with name membranes-10-00202-i006.jpg log P = 3.6–3.8
MW: 324.392 g/mol
Concentration range:
50–100 ng/mL
0.15–0.3 µmol/L